منابع مشابه
Infectious Protein Particle Prions
Transmissible spongiform encephalopathies (TSEs), otherwise known as prion disorders, are fatal diseases causing neuro degeneration in a wide range of mammalian hosts, including humans. The causative agent prions are thought to be composed of a rogue isoform of the endogenous prion protein (PrP).Prion diseases or TSEs are a group of rare but fatal neurological disorders that affect humans and a...
متن کاملAnimal Prions Are a New Type of Infectious Agents Prions
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein–protein interactions. Until the 1990s, the prion phenomenon was associated with the single...
متن کاملPrions: protein aggregation and infectious diseases.
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative diseases that affect humans and a large variety of animals. The infectious agent responsible for TSEs is the prion, an abnormally folded and aggregated protein that propagates itself by imposing its conformation onto the cellular prion protein (PrPC) of the host. PrPC is necessary for prion replication and ...
متن کاملIn Vitro Generation of Infectious Scrapie Prions
Prions are unconventional infectious agents responsible for transmissible spongiform encephalopathy (TSE) diseases. They are thought to be composed exclusively of the protease-resistant prion protein (PrPres) that replicates in the body by inducing the misfolding of the cellular prion protein (PrPC). Although compelling evidence supports this hypothesis, generation of infectious prion particles...
متن کاملPrions Adhere to Soil Minerals and Remain Infectious
An unidentified environmental reservoir of infectivity contributes to the natural transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and elk. Prion infectivity may enter soil environments via shedding from diseased animals and decomposition of infected carcasses. Burial of TSE-infected cattle, sheep, and deer as a means of disposal has resulted in ...
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ژورنال
عنوان ژورنال: Prion
سال: 2017
ISSN: 1933-6896,1933-690X
DOI: 10.1080/19336896.2017.1283464